Tvaksipim

each bottle contains:

• Cefepime USP 1 g (as cefepime hydrochloride) mixture of sterile cefepime hydrochloride and sterile arginine

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• pneumonia (moderate to severe) caused by Streptococcus pneumoniae (including cases of association with concomitant bacteremia), Pseudomonas aeruginosa, Klebsiella pneumoniae or Enterobacter spp.;
• febrile neutropenia (empirical therapy);
• complicated and uncomplicated urinary tract infections (including pyelonephritis) caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis;
• uncomplicated skin and soft tissue infections caused by Staphylococcus aureus (methicillin-sensitive strains only), Streptococcus pyogenes;
• complicated intra-abdominal infections (in combination with metronidazole) caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter spp., Bacteroides fragilis.

Prevention of infections during abdominal surgery.

Adults and adolescents over 16 years of age or children weighing more than 40 kg: IV infusion (over at least 30 minutes) or IM (only for complicated or uncomplicated mild to moderate urinary tract infections caused by E. coli) .

Pneumonia (moderate to severe) caused by Streptococcus pneumoniae (including cases of association with concomitant bacteremia), Pseudomonas aeruginosa, Klebsiella pneumoniae or Enterobacter spp.: IV 1-2 g every 12 hours for 10 days.

Febrile neutropenia (empirical therapy): IV 2 g every 8 hours for 7 days or until neutropenia resolves.

Complicated or uncomplicated urinary tract infections of mild to moderate severity caused by E. coli, Klebsiella pneumoniae, Proteus mirabilis: IV or IM (only for infections caused by E. coli) 0.5-1 g every 12 hours intravenously within 7-10 days.

Severe complicated or uncomplicated urinary tract infections (including pyelonephritis) caused by E. coli or Klebsiella pneumoniae: IV 2 g every 12 hours for 10 days.